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Self-medication is an important pillar of healthcare

… and as with treatment prescribed by a doctor, it should be undertaken on the basis of the available evidence. Evidence for Self-Medication (EfSM) presents compact reviews of relevant studies on OTC medicines and active substances in order to enable pharmacists and other healthcare professionals to provide the best possible – and evidence-based – advice on self-medication. 


All EfSM articles have been peer-reviewed. They are available in German and English, and some of them in other languages ​​as well.

Omeprazole vs. Poliprotect®

Clinical trial demonstrating non-inferiority of Poliprotect for heartburn and epigastric pain in patients without erosive esophagitis

A randomised, controlled, multicentre, double-blind and double-masked study confirmed the efficacy of Poliprotect®, a molecular complex of natural ingredients designed for the protection of the gastroesophageal mucosa, contained in the medicinal product NeoBianacid®. Poliprotect was non-inferior to the standard dose of omeprazole (20 mg/day) in the treatment of symptoms of non-erosive gastroe ...

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Author: Frederick HerbstEFSM: 2023;3:230055DOI: 10.52778/efsm.23.0055Date: 17.12.2023

Bioceramic materials emitting infrared radiation for musculoskeletal pain relief

Musculoskeletal (MSK) disorders are the leading cause of chronic pain, physical, functional impairment and loss of quality of life. About one in three people worldwide is suffering from MSK pain. The biological effects of bioceramic materials as Infrared-C emitters on body tissues and their benefits to the self-management of MSK disorders, are the subject of current interest.

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Author: Bill Giannakopoulos, PharmD, Mohamed Amessou, PhD, MBA and Eva Koscova, MD, PhD, MBA, CVTI SREFSM: 2023;3:230049DOI: 10.52778/efsm.23.0049Date: 17.12.2023

Promoted to the highest evidence class: meta-analysis supports the evidence for EA 575® in treating…

In self-limiting diseases such as acute respiratory infections, patients primarily expect relief of their symptoms, the aim being to reduce suffering and thus improve their quality of life. The results of a meta-analysis of two studies conducted in line with recognized scientific standards show that the positive effects of the dry ivy leaf extract EA  575® are visible and subjectively noticea ...

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Author: Dr Lukas Uebbing and Dr Simon BraunEFSM: 2023;3:230041DOI: 10.52778/efsm.23.0041Date: 17.10.2023

Bacillus clausii's protective and restorative mechanisms in PPI-induced gut imbalance using SHIME …

Long-term use of proton pump inhibitors (PPI) may lead to gut flora imbalance, which may be restored using probiotics. The study demonstrated the probiotic effects of B. clausii on gut microbiota health following PPI-induced dysbiosis using the Simulator of the Human Intestinal Microbial Ecosystem® (SHIME) model. The probiotic specifically improved microbial diversity and butyrate levels, among ot ...

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Author: Zefferino Righetto, Daniel Marquez and Marcos Perez III, MDEFSM: 2023;3:230034DOI: 10.52778/efsm.23.0034Date: 05.10.2023

Perceived effectiveness and increased quality of life after Macrogol 4000 use in patients with …

With a prevalence of 14 – 30% in Spain, constipation impacts quality of life (QoL) and general well-being in the affected population. A survey conducted through Spanish pharmacies among 100 consumers who purchased Macrogol  4000 to alleviate constipation symptoms, evaluated their perception on QoL improvement and effectiveness on constipation symptoms. After 14 days of treatment, a ...

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Author: Georgina Logusso, Nuno Correia, Alexia Aran and Maria MilitaoEFSM: 2023;3:230030DOI: 10.52778/efsm.23.0030Date: 25.09.2023

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Featured article

Real-world data demonstrate added value of cineole over nasal spray monotherapy for rhinosinusitis

In rhinosinusitis, taking cineole capsules on their own or combined with other drugs can improve quality of life better than monotherapy with decongestant nasal sprays.

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