Self-medication is an important pillar of healthcare

Metamizole is a drug with many years of use in some countries, and a large number of patients are exposed to its pharmacologic effects. The safety assessments have been done decades ago; therefore, it is worth summarizing the current state of knowledge of its benefit-risk profile.

The gastrointestinal system exhibits circadian fluctuations in activity that are under control of central and peripheral mechanisms. Disturbance of such rhythms may be associated with symptoms like constipation. Available evidence shows that stimulant laxatives such as bisacodyl can act synchronized on circadian colonic fluctuations helping to restore physiological gut rhythms.

International guidelines are commonly integrating complementary and integrative approaches into the management of musculoskeletal pain. This improves overall well-being while concomitantly reducing the reliance on conventional pharmacological treatments and the associated risk of side effects.

Non-alcoholic fatty liver disease (NAFLD), also known as metabolic associated fatty liver disease or MAFLD, is one of the most common liver diseases worldwide. Although NAFLD is associated with metabolic risk factors, up to 40% of patients with NAFLD are not obese but can still be considered metabolically unhealthy. Current treatment recommendations for NAFLD focus on lifestyle interventions (weig ...

Fatigue negatively impacts quality of life even in otherwise healthy individuals. Recent systematic reviews provide mechanistic plausibility for these effects. In addition, a recent study demonstrates that a combination of vitamins, minerals and Panax ginseng root dry extract (G115®) improves various domains of fatigue in real life.