Fatigue is a common presenting complaint in primary care, which negatively impacts work performance, family life, and social relationships . Alleviation of fatigue and maintenance of good health has been reported as the most common motivation for taking nutritional supplements in the general public. After having eliminated underlying diseases causing fatigue, physicians usually promote a healthy lifestyle, including a balanced diet and sufficient sleep. However, they are looking for recommendations and means to alleviate fatigue and its consequences beyond those general measures [1, 2].
Extracts of Chinese/Korean ginseng (Panax ginseng C. A. Meyer) root have been used for centuries in traditional medicine for general weakness. In addition, various preclinical (in vitro and animal) and randomized controlled clinical studies demonstrated the benefit of supplementation with Panax ginseng on various parameters related to fatigue . In particular, a specific standardized ginseng extract containing 4% of ginsenosides (G115®) formulated or not with vitamins and minerals was studied over the last 40 years [6, 7].
Recently, a 3-months open-label study was performed in healthy subjects who were suffering from non-disease-related fatigue for more than two weeks. Daily supplementation with a combination of vitamins, minerals and G115® led to a consistent and meaningful decrease (p < 0.0001) of self-perception of fatigue compared to the beginning of the study. Fatigue was evaluated at baseline and after 15, 30, 60 and 90 days of supplementation, using the validated Multidimensional Fatigue Inventory (MFI) questionnaire . Compared with baseline values, mean self-perception of general fatigue was reduced by −7.55 units [95% CI: −8.44; −6.66] (−41.8%, p < 0.0001) at 90 days. All assessed perception ratings (including mental and physical fatigue) were significantly and steadily improved from two weeks after supplementation up to study’s end (Fig. 1). It was concluded that daily intake of Panax ginseng G115® extract formulated with vitamins and minerals improves self-perception of fatigue and energy in a fatigued adult population.
Fig. 1. Effects of supplementation with a combination of vitamins, minerals and Panax ginseng root dry extract in 103 healthy subjects presenting fatigue. Data are means with their 95% confidence intervals of general, mental and physical fatigue subscales of MFI questionnaire. **: p < 0.0001 vs. baseline after Dunnett correction.
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Conflict of interest: A.-L. Tardy and L. Noah are employees of Sanofi.
Disclosure: Medical writing and publication funded by Sanofi.