Intranasal triamcinolone acetonide effectively improves nasal symptoms and quality of life in patients with perennial allergic rhinitis
The post hoc efficacy publication assessed weekly changes in rTNSS for the total score (range: 0–16) and each of its four components and the proportion of patients reporting at least a 50% or 75% reduction in symptoms [3]. Both total score (Fig. 1) and individual symptom scores for sneezing, nasal itching, rhinorrhea and nasal obstruction progressively declined over time; such symptom improvement was statistically significant at each time point with both treatments. Triamcinolone showed continuous and consistent improvement in total rTNSS scores and for individual symptoms through the 4 weeks treatment period.
Fig. 1. Least square change from baseline in total rTNSS in the per protocol population. Reproduced with permission from [3]
rTNSS = reflective Total Nasal Symptom Score; TAA = triamcinolone acetonide; FP = fluticasone propionate
The second study examined weekly QoL changes using the Rhinoconjunctivitis Qualify of Life questionnaire (miniRQLQ) [4]. Both treatments significantly improved the miniRQLQ scores, both overall and the five individual domains, including activity limitations and practical problems. Similar to symptom improvement, there was progressive improvement over time that was statistically significant at each weekly time points over the 4 weeks treatment period (Fig. 2).
Fig. 2. Least square mean changes in overall miniRQLQ. Reproduced with permission from [4].
In conclusion, intranasal triamcinolone demonstrated to be an effective treatment for adults with perennial AR that continuously and consistently improved nasal symptoms, as well as quality of life measures and was well tolerated over the 4 weeks of treatment.
Literature
- Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008 Apr;63 Suppl 86:8–160.
- Karaulov AV, Vylegzhanina T, Ovchinnikov A, Chernikova M, Nenasheva N. Triamcinolone acetonide versus fluticasone propionate in the treatment of perennial allergic rhinitis: a randomized, parallel-group trial. Int Arch Allergy Immunol 2019;179:142–51.
- Karaulov AV, Ilina NI, Shartanova N, Maslakov A, Lucio L. Triamcinolone acetonide in the treatment of perennial allergic rhinitis: a post hoc efficacy analysis of a phase III study performed in russia. Int Arch Allergy Immunol 2021 Sep 14:1–8. Online ahead of print.
- Karaulov AV, Nenasheva N, Smolkin Y, Maslakov A, Lucio L. Triamcinolone acetonide in the treatment of perennial allergic rhinitis: a post hoc analysis of quality of life during a phase III study. Int Arch Allergy Immunol 2021 Sep 6:1–8. Online ahead of print.
Conflict of interest: M. Amessou, E. Leshcheva, A. Maslakov and P. Venkataraman are employees of Sanofi.
Disclosures: Medical writing and publication funded by Sanofi-Aventis Deutschland GmbH.