The post hoc efficacy publication assessed weekly changes in rTNSS for the total score (range: 0–16) and each of its four components and the proportion of patients reporting at least a 50% or 75% reduction in symptoms . Both total score (Fig. 1) and individual symptom scores for sneezing, nasal itching, rhinorrhea and nasal obstruction progressively declined over time; such symptom improvement was statistically significant at each time point with both treatments. Triamcinolone showed continuous and consistent improvement in total rTNSS scores and for individual symptoms through the 4 weeks treatment period.
Fig. 1. Least square change from baseline in total rTNSS in the per protocol population. Reproduced with permission from 
rTNSS = reflective Total Nasal Symptom Score; TAA = triamcinolone acetonide; FP = fluticasone propionate
The second study examined weekly QoL changes using the Rhinoconjunctivitis Qualify of Life questionnaire (miniRQLQ) . Both treatments significantly improved the miniRQLQ scores, both overall and the five individual domains, including activity limitations and practical problems. Similar to symptom improvement, there was progressive improvement over time that was statistically significant at each weekly time points over the 4 weeks treatment period (Fig. 2).
Fig. 2. Least square mean changes in overall miniRQLQ. Reproduced with permission from .
In conclusion, intranasal triamcinolone demonstrated to be an effective treatment for adults with perennial AR that continuously and consistently improved nasal symptoms, as well as quality of life measures and was well tolerated over the 4 weeks of treatment.
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Conflict of interest: M. Amessou, E. Leshcheva, A. Maslakov and P. Venkataraman are employees of Sanofi.
Disclosures: Medical writing and publication funded by Sanofi-Aventis Deutschland GmbH.