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The probiotic Bacillus clausii is an effective treatment of acute diarrhea in children


A systematic review and meta-analysis confirms that the probiotic Bacillus clausii is an effective treatment for acute diarrhea in childhood. It shortens the duration of diarrhea and associated hospit ...

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Author: Marcos III Perez, MD and Dorothea M. Greifenberg, PhDEFSM: 2022;2:220003DOI: 10.52778/efsm.22.0003Date: 21.01.2022

Better understanding of “21st century headache” via real-world data


Throughout the world, headache is one of the main causes of limitations in daily life and/or unfitness to work. 50% of sufferers never consult a doctor and instead turn to self-medication. A recently ...

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Author: Luminita Constantin, MD, Marion Eberlin, PhD, Iva Igracki Turudic, MD and Martin C. Michel, MDEFSM: 2022;2:220001DOI: 10.52778/efsm.22.0001Date: 17.01.2022

Bisacodyl: comprehensive findings direct effective and safe use in constipation


For the first time since bisacodyl was licensed in the 1950s, an up-to-date review has provided a thorough summary of the pharmacological and clinical data concerning this prokinetic and secretagogic ...

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Author: Sabine Landes, PhD, Marion Eberlin, PhD and Robert Lange, PhDEFSM: 2021;1:210338DOI: 10.52778/efsm.21.0338Date: 06.12.2021

Essential phospholipids in fatty liver diseases


The liver is an important organ of metabolism and the immune system. An oversupply of carbohydrates or excessive alcohol consumption can trigger inflammatory processes and lead to the development of f ...

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Author: Assoc. Prof. Peter Minárik, MD, PhD, MSc and Eva Koscova MD, PhD, MBAEFSM: 2021;1:210346DOI: 10.52778/efsm.21.0346Date: 05.12.2021

Allergic Rhinitis and air pollution: New clinical evidence with fexofenadine hydrochloride 180 mg


Exposure to air pollutants and climate change are contributing factors of increasing prevalence and allergic rhinitis (AR) symptom exacerbation. Fexofenadine 180 mg has been shown effective in relievi ...

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Author: Margarita Murrieta-Aguttes, MD and Marina Volonte, DVMEFSM: 2021;1:210332DOI: 10.52778/efsm.21.0332Date: 29.11.2021

Dexibuprofen – a portrait


Dexibuprofen, the pharmacologically active enantiomer of ibuprofen, shows good efficacy in both acute and chronic pain. The review summarises study results that confirm dexibuprofen as an effective an ...

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Author: Andrea Gažová, Doc. PharmD, PhD, Jan Kyselovic, PharmD, PhD and Eva Koscova MD, PhD, MBAEFSM: 2021;1:210324DOI: 10.52778/efsm.21.0324Date: 29.10.2021

Micronutrient combination plus DHA during pregnancy


The multicentre, parallel, randomised, controlled study assessed the impact of once-daily supplementation with 12 vitamins, 6 minerals and docosahexaenoic acid (DHA) on maternal biomarkers and child-s ...

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Author: Jens Seibel, LeverkusenEFSM: 2021;1:210330DOI: 10.52778/efsm.21.0330Date: 26.10.2021

Macrogol 4000: evidence-based self-medication for functional constipation


Macrogol preparations are one of the first-line treatments for constipation in both, children and adults. A review has confirmed the efficacy and tolerability of macrogol 4000 compared with lactulose ...

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Author: Marion Eberlin, PhD and Sabine Landes, PhDEFSM: 2021;1:210315DOI: 10.52778/efsm.21.0315Date: 12.10.2021

Evidence for the treatment of acute joint pain with topical diclofenac gels


An ex-vivo study on human skin samples showed that topical diclofenac not only penetrates the skin but also forms a reservoir of the drug in the epidermis. Confirmation that the drug reaches the site ...

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Author: Daniela DeutschEFSM: 2021;1:210313 DOI: 10.52778/efsm.21.0313Date: 22.09.2021

Relief of acute cough by cough syrup with mucoprotection


Two randomised, blind, controlled, multicentre studies investigated the therapeutic effect of a chemical and mechanical barrier in the upper airways produced by polysaccharide-resin-honey based cough ...

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Author: Tobias Mück, PhDEFSM: 2021;1:210004DOI: 10.52778/efsm.21.0004Date: 16.08.2021