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Do caffeine-containing combination analgesics cause sleepless nights?


No relevant effects on the sleep quality of subjects were found in two studies in which ibuprofen combined with 100 mg caffeine was taken three times daily. Of a total of 538 patients, medication-indu ...

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Author: Thomas Weiser, PhDEFSM: 2021;1:210015DOI: 10.52778/efsm.21.0015Date: 16.08.2021

Laxatives in children? New study confirms effectiveness and tolerability of long-term bisacodyl


A retrospective study investigated the efficacy and tolerability of long-term and regular use of bisacodyl in children. Even when taken over a long period (mean duration of treatment: 14 months), bisa ...

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Author: Marion Eberlin, PhDEFSM: 2021;1:210021DOI: 10.52778/efsm.21.0021Date: 16.08.2021

Macrogol – guideline-based treatment for constipation


An increase in stool frequency and an improvement in stool consistency play a decisive role in the relief of constipation. International as well as national guidelines recognise the positive effect of ...

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Author: Marion Eberlin, PhD and Tanja Schütt, PhDEFSM: 2021;1:210020DOI: 10.52778/efsm.21.0020Date: 16.08.2021

Efficacy and tolerability of ambroxol in children


A review summarised extensive clinical, published and as yet unpublished data on the use of ambroxol in children and evaluated the results. Ambroxol was shown to be an effective secretolytic treatment ...

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Author: Tobias Mück, PhDEFSM: 2021;1:210019DOI: 10.52778/efsm.21.0019Date: 16.08.2021

From virus deactivation in-vitro to clinical relevance: a glycerol and cod trypsin-containing mouth…


Trypsin combined with glycerol caused the deactivation of common cold viruses in vitro. A pilot study and a comparative multicentre study investigated the in vivo reduction in viral load and the impro ...

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Author: Tanja Schütt, PhD and Matthias Löhn, PhDEFSM: 2021;1:210018DOI: 10.52778/efsm.21.0018Date: 16.08.2021

Fall asleep quickly – wake up refreshed!


Various causes, including stress and increased media consumption, lead to a reduction or even total absence of the release of endogenous melatonin, followed by problems falling asleep. According to th ...

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Author: Tanja Schütt, PhDEFSM: 2021;1:210017DOI: 10.52778/efsm.21.0017Date: 16.08.2021

Analgesics with effect enhancers – combination analgesics with caffeine


A review by the Cochrane Collaboration compared the analgesic effects of a common analgesic with a combination of the analgesic and caffeine. The addition of caffeine significantly increased the propo ...

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Author: Thomas Weiser, PhDEFSM: 2021;1:210016DOI: 10.52778/efsm.21.0016Date: 16.08.2021

Recent meta-analysis on the efficacy of peppermint oil in irritable bowel syndrome


The meta-analysis demonstrated that peppermint oil is an effective and safe medicinal agent for treating the symptoms of irritable bowel syndrome. In seven clinical studies, peppermint oil was clearly ...

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Author: Harald Weigmann, PhDEFSM: 2021;1:210013DOI: 10.52778/efsm.21.0013Date: 16.08.2021

Caffeine – stimulating and aromatic: but safe!


The European Food Safety Authority has undertaken a comprehensive risk assessment and concluded that life-long regular consumption of caffeine of up to 400 mg daily from the age of 18 by healthy adult ...

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Author: Thomas Weiser, PhDEFSM: 2021;1:210014DOI: 10.52778/efsm.21.0014Date: 16.08.2021

Ambroxol reduces cough frequency (in the daytime and at night) and thereby improves concentration …


The pharmacy-based study questioned customers who had used one of four different dosage forms of ambroxol for acute cough. The results illustrated the therapeutic benefits of ambroxol in self-medicati ...

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Author: Tobias Mück, PhDEFSM: 2021;1:210003DOI: 10.52778/efsm.21.0003Date: 16.08.2021