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Dexibuprofen – a portrait


Dexibuprofen, the pharmacologically active enantiomer of ibuprofen, shows good efficacy in both acute and chronic pain. The review summarises study results that confirm dexibuprofen as an effective an ...

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Author: Andrea Gažová, Doc. PharmD, PhD, Jan Kyselovic, PharmD, PhD and Eva Koscova MD, PhD, MBAEFSM: 2021;1:210324DOI: 10.52778/efsm.21.0324Date: 29.10.2021

Micronutrient combination plus DHA during pregnancy


The multicentre, parallel, randomised, controlled study assessed the impact of once-daily supplementation with 12 vitamins, 6 minerals and docosahexaenoic acid (DHA) on maternal biomarkers and child-s ...

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Author: Jens Seibel, LeverkusenEFSM: 2021;1:210330DOI: 10.52778/efsm.21.0330Date: 26.10.2021

Macrogol 4000: evidence-based self-medication for functional constipation


Macrogol preparations are one of the first-line treatments for constipation in both, children and adults. A review has confirmed the efficacy and tolerability of macrogol 4000 compared with lactulose ...

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Author: Marion Eberlin, PhD and Sabine Landes, PhDEFSM: 2021;1:210315DOI: 10.52778/efsm.21.0315Date: 12.10.2021

Evidence for the treatment of acute joint pain with topical diclofenac gels


An ex-vivo study on human skin samples showed that topical diclofenac not only penetrates the skin but also forms a reservoir of the drug in the epidermis. Confirmation that the drug reaches the site ...

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Author: Daniela DeutschEFSM: 2021;1:210313 DOI: 10.52778/efsm.21.0313Date: 22.09.2021

Pharmacokinetics of ibuprofen: comparison of the fixed combination of ibuprofen plus caffeine with …

Results of two single-dose studies (randomised, single centre, crossover, open-label)


Analgesics containing readily soluble ibuprofen (e.g. as the lysinate) were developed with the aim of ensuring a more rapid relief of pain than ibuprofen acid through faster absorption in the gastroin ...

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Author: Thomas Weiser, PhDEFSM: 2021;1:210007DOI: 10.52778/efsm.21.0007Date: 16.08.2021

From virus deactivation in-vitro to clinical relevance: a glycerol and cod trypsin-containing mouth…


Trypsin combined with glycerol caused the deactivation of common cold viruses in vitro. A pilot study and a comparative multicentre study investigated the in vivo reduction in viral load and the impro ...

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Author: Tanja Schütt, PhD and Matthias Löhn, PhDEFSM: 2021;1:210018DOI: 10.52778/efsm.21.0018Date: 16.08.2021

Laxatives in children? New study confirms effectiveness and tolerability of long-term bisacodyl


A retrospective study investigated the efficacy and tolerability of long-term and regular use of bisacodyl in children. Even when taken over a long period (mean duration of treatment: 14 months), bisa ...

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Author: Marion Eberlin, PhDEFSM: 2021;1:210021DOI: 10.52778/efsm.21.0021Date: 16.08.2021

Macrogol – guideline-based treatment for constipation


An increase in stool frequency and an improvement in stool consistency play a decisive role in the relief of constipation. International as well as national guidelines recognise the positive effect of ...

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Author: Marion Eberlin, PhD and Tanja Schütt, PhDEFSM: 2021;1:210020DOI: 10.52778/efsm.21.0020Date: 16.08.2021

Meta-analysis on the role of exercise in the treatment of constipation


Current guidelines recommend life-style adjustment (including more exercise) as the first measure for treating constipation. This meta-analysis investigated the influence of exercise therapy on the sy ...

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Author: Thomas Weiser, PhD and Sabine Landes, PhDEFSM: 2021;1:210001DOI: 10.52778/efsm.21.0001Date: 16.08.2021

Efficacy and tolerability of ambroxol in children


A review summarised extensive clinical, published and as yet unpublished data on the use of ambroxol in children and evaluated the results. Ambroxol was shown to be an effective secretolytic treatment ...

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Author: Tobias Mück, PhDEFSM: 2021;1:210019DOI: 10.52778/efsm.21.0019Date: 16.08.2021